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Platelet satellitism is described as an infrequent finding characterized by formation of platelet rosettes around polymorphonuclear (PMN) leucocytes, which are seen in Wright-stained peripheral blood smears prepared from EDTA-anticoagulated blood samples, but not seen when others anticoagulants such as heparin, acid-citrate dextrose, or citrate, are used. The mechanism of this platelet adhesion to PMN is not understood, but there is evidence that autoantibodies directed to the glycoprotein IIb/IIIa complex of the platelet membrane, as well against the neutrophil Fc gama receptor, are involved (1). It is possible that the epitopes for those antibodies are usually hidden in leukocyte and platelet membranes and that membrane changes induced by EDTA expose them; which would explain why satellitism is observed exclusively in blood anticoagulant with EDTA.

Palabras clave: Platelet satellitism.

2004-08-05   |   888 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.2. Abril-Junio 2004 Pags. 137-138 Rev Biomed 2004; 15(2)